![]() ![]() Stratified and random-effects meta-regression analyses were performed to search for outcome differences among studies. Two meta-analyses were undertaken to provide a summary estimate of change in treatment outcomes and to evaluate the effect of CTMs one used the standardized mean change between the pretest and posttest, and the other was a classical meta-analysis. ![]() Longitudinal studies were selected if they investigated the outcomes of CTMs. Methods: We searched eight databases up to June 13, 2019, for relevant trials and natural experiments. The current meta-analysis reviewed studies reporting broader outcomes in children with ASD who had ever participated in a CTM and examined the predictors of developmental gains. Numerous studies have suggested that CTMs can improve short-term outcomes, but little is known about precise outcome information in childhood. ![]() Background: Early comprehensive treatment models (CTMs) have been developed as effective treatments for children with autism spectrum disorder (ASD).
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